Multiple Symmetric Lipomatosis: A Cross-Sectional Study to Investigate Clinical Features and Patients’ Quality of Life

Within the subcutaneous adipose tissue diseases, multiple symmetric lipomatosis (MSL) (syn.: Launois Bensaude Syndrome, Morbus Madelung, benign lipomatosis) is rare. The pathogenesis of MSL remains unclear. We investigated largest German cohort patients to obtain anamnestic data and quality life with a standard questionnaire. Twenty-nine confirmed were included filled in questionnaire designed for this study. assessed common factors, such as (EQ-5D-3L) subjective treatment goals success (“Patient-Benefit-Index-Lymphedema”, PBI-L). gender distribution involved study was m/f: 1/4 (male: n = 6 (21%); female 23 (79%)). While exact pathophysiology unclear, subset patients’ positive family history suggests strong genetic factor, sometimes compatible autosomal dominant inheritance. Patients showed lower health states (EQ VAS Score: m 51, sd 24, range 0–90) than norm population (m 77). Around two thirds (68%) reported relevant benefits therapy (liposuction/lipectomy). In our about one third MSL-like features. Additionally, at least some patients, inheritance, seems possible major driver development. Alcohol consumption development has be regarded controversial issue. suffering from have clear decrease marked wish treatment.